“The Transition Between Academia and Industry” Talk presented on November 17, 2020 , Invited by the Structural Biology and Biophysics Group at Purdue University, West Lafayette IN
“Synthesis and antibacterial activity of 1,5-diaryl-3-methyl-pyrazoles” Richter, Katelyn B.; Esan, Taiwo; Grote, Dakota L.; Prinsell, Michael Robert; Horn, James R.; Hagen, Timothy J., ACS National Meeting & Exposition, Philadelphia, PA, United States, March 22-26, 2020 MEDI-0339
“Synthesis of substituted benzothiazole derivatives as PDE4 inhibitors using the Hugerschoff reaction” Kondam, Chaitanya; Lin, Randy; Hagen, Timothy J.43rd Great Lakes Regional Meeting of the American Chemical Society Lisle IL May 1-4 (2019).
“Inhibition of carbonic anhydrases by acetazolamide and ethoxzolamide analogs” Stewart, Christopher; Grote, Dakota; Watkins, Sydney M.; Kazimierski, Diana; Pomeroy, Julia; Johnson, Lauren;Tay, Gidget C.; Horn, James; Hagen, Timothy J. 43rd Great Lakes Regional Meeting of the American Chemical Society, Lisle, IL, United States, May 1-4 (2019).
“Investigation of tryptophan hydroxamate as a potential inhibitor of 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase (IspF) in Burkholderia pseudomallei Grote, Dakota; Blain, Joy M.; Watkins, Sydney M.; Muller, Chante; Ranieri, Gina; Walter, Richard; Horn, James; Hagen, Timothy J. 43rd Great Lakes Regional Meeting of the American Chemical Society, Lisle, IL, United States, May 1-4 (2019).
The synthesis of fluorescent compounds for characterization of IspF ligands Stewart, Christopher; Grote, Dakota; Watkins, Sydney M.; Blain, Joy M.; Sayles, Amber; Horn, James; Hagen, Timothy J.43rd Great Lakes Regional Meeting of the American Chemical Society, Lisle, IL, United States, May 1-4 (2019).
Development of a fluorescent binding assay targeting 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase (IspF). Grote, D.L., Watkins, S.M., Stweart, C.G., Hagen, T.J., and Horn, J.R. (2019) Presentation at 33nd Annual Gibbs Conference on Biothermodynamics, Carbondale, IL. October 5-8, 2019.
Analysis of fluorescent thermal shift screening hits against Burkholderia pseudomallei IspF Watkins, Sydney; Grote, Dakota; Muller, Chante; Blain, Joy; Luan, Chi-Hao; Horn, James; Hagen, Timothy Abstracts of Papers, 255th ACS National Meeting & Exposition, New Orleans, LA, United States, March 18-22, 2018 (2018), MEDI-381.
Dakota Grote, Joy Blain, Sydney Watkins, Christopher Stewart, Timothy Hagen, and James Horn. Development of a High-Throughput Assay to Determine Binding Affinities of Potential Inhibitors of IspF in Burkholderia pseudomallei. (2018) Presentation at 32nd Annual Gibbs Conference on Biothermodynamics, , Carbondale, IL, October 6-9, 2018.
“Design, synthesis, and evaluation MEP pathway inhibitors”. Timothy J. Hagen, Invited Lecture and Recruiting Trip to Western Illinois University, April 28, 2017.
“Design, synthesis, and evaluation of Burkholderia pseudomallei MEP pathway inhibitors”Timothy J. Hagen, Invited Lecture and Recruiting Trip to Knox College March 2, 2017.
“Evaluation of 2-amino-pyrimidine derivatives as antimicrobial agents and IspF inhibitors” Watkins S, Ghose D, Muller CA, Zhang Z, Blain JM, Lazowski Z, McDonald ST, Riggins-Walker T, Horn JR, Meganathan R, Hofstetter H, Hagen TJ, 253rd ACS National Meeting & Exposition, San Francisco, CA, United States, April 2-6, 2017, MEDI-261.
“Derivatives of L-Tryptophanhydroxamic Acid as Potential Inhibitors of Burkholderia pseudomallei IspF” Chanté A. Muller, Dakota L. Grote, Sydney M. Watkins, Debarati Ghose, Joy M. Blain, Megan O. Decker, Heike Hofstetter, R. Meganathan, James R. Horn, Timothy J. Hagen 253rd ACS National Meeting & Exposition, San Francisco, CA, United States, April 2-6, 2017.
Katarzyna B. Hoerchler, Gidget Tay, Brian E. Hartnett, Allison F. Carr, James R. Horn, and Timothy J. Hagen “Synthesis and Evaluation of 4-Quinazolinone Inhibitors of IspE Enzyme “8th Chicago Organic Symposium, 30 Sep 2017.
Characterization of Tryptophan Hydroxamate as a Potential Inhibitor of the MEP Pathway by targeting IspF in Burkholderia pseudomallei and Escherichia coli Gibbs Conference October 2017 Carbondale, IL.
“Inhibitors of plasmodium falciparum methionine aminopeptidase 2 with antimalarial activities Wangtrakuldee, Phumvadee; Sciotti, Richard J.; Miter, Gabriel A.; Zhang, Zheng; Horn, James R.; Hagen, Timothy J. ACS National Meeting & Exposition, Dallas, TX, United States, March 16-20, 2014.
"Identification of METAP2 Inhibitors Using Fluorescence Based Enzymatic Assay". Flor Navarro, Phumvadee Wangtrakuldee, James Horn, and Timothy Hagen, Research and Artistry Northern Illinois University April 22, 2014.
“Fragment Based Drug Discovery Analog Activity with respect to the MEP Pathway” Sterling Pollard, Zheng Zhang, James Horn, Timothy Hagen Research and Artistry Northern Illinois University April 22, 2014.
“IspD Inhibition Using a Fragment Approach for Antimalarial, Antibacterial, and Herbicidal Properties” Jeremy Troxell, Michael Thompson, Joy Blain, Timothy Hagen & James Horn, Research and Artistry Northern Illinois University April 22, 2014.
“Inhibitors of Isoprenoid Biosynthesis as Novel Anti-infective Agents” Chicago Innovation Showcase, Timothy J. Hagen, August 5, 2014.
“Development of Novel Anti-Infective and Herbicidal Agents” Timothy Hagen, NIU Venture Grant Opportunity, April 23, 2014.
Joy M. Blain, Zheng Zhang, Gashaw M. Goshu, Timothy J. Hagen, and James R. Horn. Investigation of Small Molecule-Enzyme Interactions of B. pseudomallei IspF. 28th Annual Gibbs Conference on Biothermodynamics, national meeting, September 20-23, 2014.
“Investigation of Small Molecule-Enzyme Interactions of B. pseudomallei IspF” Joy M. Blain, Zheng Zhang, Gashaw M. Goshu, Timothy J. Hagen, and James R. Horn, Center for Molecular Innovation and Drug Discovery's 19th Annual Drug Discovery Symposium October 9, 2014.
“Discovery of Rickettsia prowazekii Methionine aminopeptidase Inhibitors” Phumvadee Wangtrakuldee, Congling Chen, Bart Staker, Travis Helgren, John M. Wilk, James R. Horn, and Timothy J. Hagen. October 9, 2014.
“Investigation of Burkholderia pseudomallei IspF Small Molecule Inhibitors” Joy M. Blain, Zheng Zhang, Gashaw M. Goshu, Timothy Hagen, and James R. Horn, First annual MEPtogether, Washington University, Innsbrook, Missouri November 21-23 2014.
“MEP-Pathway Inhibition” Timothy Hagen First annual MEPtogether, Washington University, Innsbrook, Missouri November 22, 2014"Identification of METAP2 Inhibitors Using Fluorescence Based Enzymatic Assay". Flor Navarro, Phumvadee Wangtrakuldee, James Horn, and Timothy Hagen, Research and Artistry Northern Illinois University April 22, 2014.
"Fragment Screening Hits to Lead Like Molecules for Infectious Drug targets: MEP Pathway."
Invited lecture University of Illinois Chicago, Oct. 3, 2013.
“Discovery of imidazole based IspF inhibitors”, Zhang, Z.; Goshu, G. M.; Ahern, A. D.; Kostka, A. A.; Jakkaraju, S.; Ruettiger, A.; Clare, M.; Sciotti, R.; Lee, P. J.; Horn, J. R.; Begley, D. W.; Hagen, T. J. American Chemical Society National meting Indianapolis IN September 8-12 2013; pp MEDI-56.
“Discovery of inhibitors of Burkholderia pseudomallei methionine aminopeptidase with antibacterial activity,” Wangtrakuldee, P.; Byrd, M. S.; Campos, C. G.; Henderson, M. W.; Masoudi, A.; Myler, P. J.; Cottter, P. A.; Horn, J. R.; Hagen, T. J. American Chemical Society National meting Indianapolis IN September 8-12 2013; pp MEDI-49.
Zeller, W. E.; Powell, J. M.; Hagen, T. J.; Helgren, T. R.; Lindquist, S. J. In Impacts of flavanoid monomers and simple hydrolyzable tannins on ammonia emissions from dairy manure, American Chemical Society National meting New Orleans LA April 7-11 2013; pp AGFD-328.
"Discovery of new anti-infective agents using organic synthesis and structural biology".
Roosevelt University, March 5, 2012.
"Design and synthesis of phosphodiesterase 4D (PDE4D) allosteric modulators and MEP pathway inhibitors" Invited lecture at NIH on November 16, 2011.
“Concise synthesis of a PDE4 partial modulator” 16th Annual Drug Discovery Symposium at Northwestern University Wednesday, October 12, 2011.
“Discovery and Synthesis of IspF Inhibitors” 42nd National Organic Symposium June 8, 2011
“Design of MEP Pathway Inhibitors” Invited presentation at Argonne National Labs / Center for Molecular Design and Drug Discovery March 29, 2011.
“Design and synthesis of phosphodiesterase 4D (PDE4D) allosteric modulators”, Invited Lecture Indiana University Northwest, February 28, 2011.
Discovery and Synthesis of IspF Inhibitors” 3rd Annual Chicago Organic Symposium. University of Illinois Chicago, February 11, 2011.
“Design and synthesis of phosphodiesterase 4D (PDE4D) allosteric modulators”, Invited Lecture Knox College, November 4, 2010.
2-Imino-pyrrolidine amino acids as inhibitors of human nitric oxide synthase. Hagen, Timothy J.; Invited lecture, Loyola University, Chicago IL. September 13, 2001.
2-Imino-pyrrolidine amino acids as inhibitors of human nitric oxide synthase. Hagen, Timothy J.; Bergmanis, Arija A.; Tsymbalov, Sofya; Kramer, Steven W.; Spangler, Dale; Moore, William M.; Jerome, Gina; Manning, Pamela T.; Kornmeier, Christina; Connor, Jane R.; Pitzele, Barnett S.; Hallinan, E. Ann. Abstracts of Papers, MEDI-249 222nd ACS National Meeting, Chicago, IL, August 26-30, 2001.
Inhibitors of Human Nitric Oxide Synthase from Substituted Cyclic Amidinium Salts. D.W. Hansen, K.B. Peterson, F.S. Tjoeng, T.J. Hagen, M.V. Toth, S.S. Metz, K.F. Fok, Zupec, M.E., B.S. Pitzele, W.M. Moore, G.M. Jerome, P.T. Manning, M.G. Currie, R.K. Webber, 5th Chemical Congress of North America, Cancun, Mexico, 11/12/97.
Alternative Successful Syntheses of a Beta-ethynyl Amino Acid Ester Critical to the Preparation of a Clinically Effective Antiplatelet Agent. D.W. Hansen Jr., K.B. Peterson, E.A. Hallinan, T.J. Hagen, B.S. Pitzele, S. Tsymbalov, S.S. Babu, P.N. Farid, K.A. Babiak, and S.T. Nugent, 79th Canadian Society of Chemistry (CSC) Conference, St. Johns , Newfoundland, Canada 6/23/96.
The t-Boc Group as an Activator for a’-Lithiation: Synthesis of 11-Substituted Dibenzoxazepines. ACS 25th Great Lakes Regional Meeting, Marquette University, Milwaukee, Wisconsin, June 2, 1992.
Synthetic and Computer Assisted Approaches to the Pharmacophore of the Benzodiazepine Receptor Inverse Agonist Site; Invited Lecture, Department of Chemistry, Illinois State University, Normal Il, January 24, 1992.
The Synthesis of Novel 6-Substituted b -Carbolines Which Behave as Benzodiazepine Receptor Antagonists or Inverse Agonists; ACS National Meeting, Denver, Colorado, April 5, 1987.
A New Class of Norharman Derivatives Which Potently Bind to Benzodiazepine receptors: 6-Substituted Derivatives That Bind at 100 nM; ACS 20th Great Lakes Regional Meeting, Marquette University, Milwaukee, Wisconsin, June 2, 1986; Abstr. 262.
Synthesis of 3,6-Disubstituted b-Carbolines Which Possess Either Benzodiazepine Antagonist or Agonist Activity; 191st ACS National Meeting, New York, New York, April 13, 1986; Medi. Abstr. 51.
Synthesis of b-Carbolines: Search for New and More Stable Valium Antagonists; ACS National Meeting, Chicago, Illinois, Sept. 28, 1985; Medi. Abstr. 86.
Synthesis of b-Carbolines: Search for New and More Stable Valium Antagonists; ACS 19th Great Lakes Regional Meeting, Purdue University, West Lafayette, Indiana, June 10, 1985.
Synthesis of b-Carbolines: Preparation of “Active” Antagonists of the Benzodiazepines; ACS Joint Regional Meeting, Western Michigan University, Kalamazoo, Michigan, May 23, 1984; Abstr. 238.
Photochemical Aromatic Cyanomethylation: Electron-Transfer versus Homolytic Substitution; 184th ACS National Meeting, Kansas City, Missouri, Sept. 12, 1982; Orgn. Abstr. 99.
Phone: 815-753-1463
Fax: 815-753-2902
Email: thagen@niu.edu