Selected Patents and Patent Applications

  1. S. Pat. Appl. Publ. (2018), US 20180271098 A1 20180927
    Hagen, Timothy J.; Thompson, Michael; Troxell, Jeremy R.; Hartnett, Brian E Oxadiazole and phenol derivatives as antibacterial and/or herbicidal agents
  1. S. Pat. Appl. Publ. (2018), US 20180221483 A1 20180809 Gaillard, Elizabeth; Karumanchi, Devi K.; Dillon, James; Friedrichs, Jason; Xu, Tao; Hagen, Timothy J Timed release of substances to treat ocular disorders
  1. Patent US20170355700A1. 2017
    Hagen TJ, Blain JM, Goshu GM, Hartnett BE, inventors; Board of Trustees of Northern Illinois University, USA . assignee. Preparation of pyrazolopyrimidines as antibacterial agents
  1. S. Patent 9,309,232 B2, Timothy J. Hagen, Zheng Zhang, Zachary Lazowski, Michael Clare and Darren W. Begley. Synthesis of novel inhibitors of isoprenoid biosynthesis. filed April 23, 2013, and issued April 12, 2016.
  1. Gaillard E, Friedrichs J, Xu T, Hagen TJ, Dillon J, inventors; Northern Illinois University, USA . assignee. Timed release of ophthalmic substances from liposomes and inverted micelles to treat ocular disorders patent WO2015023884A2. 2015.
  1. Hagen TJ, Zhang Z, Lazowski Z, Clare M, Begley DW, inventors; Northern Illinois University, USA; Emerald Biostructures, Inc. . assignee. Design and synthesis of novel inhibitors of isoprenoid biosynthesis patent WO2013163159A2. 2013.
  1. WO 2014066659, A1 “Heteroaryl compounds as inhibitors of PDE4 and their preparation” Gurney, Mark E.; Hagen, Timothy J.; Mo, Xuesheng; Vellekoop, A.; Romero, Donna L.; Campbell, Robert F.; Walker, Joel R.; Zhu, Lei May 01, 2014
  1. PCT Int. WO2013163159A2 Design and synthesis of novel inhibitors of isoprenoid biosynthesis. Hagen, T. J.; Zhang, Z.; Lazowski, Z.; Clare, M.; Begley, D. W.
  1. PCT Int. Appl. WO2009067600A2
    Biaryls as PDE4 inhibitors for treating inflammation and their preparation and pharmaceutical compositions. Singh, Jasbir; Gurney, Mark E.; Burgin, Alex; Sandanayaka, Vincent; Kiselyov, Alexander; Motta, Adalie; Schultz, Gary; Hategan, Georgeta; Hagen, Timothy.
  1. PCT Int. Appl. WO2009067621A1
    Biaryls as PDE4 inhibitors for treating inflammatory and cardiovascular disorders and their preparation and pharmaceutical compositions. Singh, Jasbir; Gurney, Mark; Burgin, Alex; Kiselyov, Alexander; Rao, Munagala; Hagen, Timothy.
  1. PCT Int. Appl. WO2009056934A1
    Preparation of 1,4-dihydronaphthyridine derivatives as therapeutic calcium channel antagonists. Cai, Cuiman; Ciske, Fred Lawrence; Duran, Joseph Edward; Fors, Kristina Sean; Hagen, Timothy Joseph; Holsworth, Daniel Dale; Jalaie, Mehran; Kennedy, Robert Michael; Leonard, Daniele; Poel, Toni-Jo; Quin, John, III.
  1. PCT Int. Appl. WO 2008050200A1
    Preparation of piperazinylmethyloxadiazoles as calcium channel antagonists. Bornemeier, Dirk Alan; Cai, Cuiman; Fors, Kristina Sean; Hagen, Timothy Joseph; Holsworth, Daniel Dale; Jalaie, Mehran; Leonard, Daniele Marie; Moody, Thomas Shaw; Take, Yukinori.
  1. PCT Int. Appl. WO2005040133A1
    Preparation of pyrimidine derivatives as IKK-2 inhibitors. Clare, Michael; Hagen, Timothy J.; Houdek, Stephen C.; Lennon, Patrick J.; Weier, Richard M.; Xu, Xiangdong.
  1. PCT Int. Appl. WO2004009582A1
    Preparation of substituted thiophene carboxamide compounds for the treatment of inflammation.      Hagen, Timothy J.; Weier, Richard M.; Xu, Xiangdong; Houdek, Stephen C.; Clare, Michael.
  1. PCT Int. Appl. WO0324936A1
    Preparation of pyrazolo[4,3-c]quinolines, chromeno[4,3-c]pyrazoles, and analogs for the treatment of inflammation.  Metz, Suzanne; Clare, Michael; Crich, Joyce Z.; Hagen, Timothy J.; Hanson, Gunnar J.; Huang, He; Houdek, Stephen J.; Stealey, Michael A.; Vazquez, Michael L.; Weier, Richard M.; Xu, Xiangdong
  1. PCT Int. Appl. WO0324935A2
    Preparation of 4,5-dihydro-1H-benzo[g]indazole-3-carboxamides for the treatment of inflammation. Bergmanis, Arija A.; Bonafoux, Dominique; Clare, Michael; Crich, Joyce Z.; Fletcher, Theresa R.; Geng, Lifeng; Hagen, Timothy J.; Hamper, Bruce C.; Hanson, Gunnar J.; Houdek, Stephen C.; Huang, He; Iula, Donna M.; Koszyk, Francis J.; Lennon, Patrick J.; Liao, Shuyuan; Liao, Subo; Metz, Suzanne; Mohler, Scott B.; Nguyen, Maria; Oburn, David S.; Owen, Thomas J.; Partis, Richard A.; Scates, Angela M.; Stealey, Michael A.; Tollefson, Michael B.; Vazquez, Michael L.; Weier, Richard M.; Wolfson, Serge G.; Xu, Xiangdong.
  1. PCT Int. Appl. WO0222562 A1
    Preparation of 2-amino-2-alkyl-5-heptenoic and -heptynoic acid derivatives useful as nitric oxide synthase inhibitors. Hansen, Donald, Jr.; Webber, Ronald Keith; Pitzele, Barnett S.; Sikorski, James; Massa, Mark A.; Hagen, Timothy J.; Grapperhaus, Margaret; Wang, Lijuan Jane; Bergmanis, Arija A.; Kramer, Steven W.; Hallinan, E. Ann.li>
  1. US patent 6,403,830 6/11/02
    “Amidino compound and salts thereof useful as nitric oxide synthase” Hansen Jr., D.W.; Bergmanis, A.A.; T.J. Hagen, E.A. Hallinan, S.W. Kramer, S. Metz, K.B. Peterson, B.S. Pitzele, F.S. Tjoeng, M.V. Toth, M. Trivedi, , R.K. Webber, S. Tsymbalov, R.E. Gapud
  1. US Patent 6,344,483, 2/5/02
    “Halogenated amidino amino acid deviratives useful as nitric oxide synthase”  Hallinan, E.A.; Hagen, T.J.; A.A. Bergmanis, Toth, M.V.; Tsymbalov, S.; Pitzele, B.S.
  1. US Patent 6,344,473, 2/5/02
    “Imidazoles useful as nitric oxide synthase inhibitors”  Hansen Jr., D.W.; Bergmanis, A.A.; T.J. Hagen, E.A. Hallinan, S.W. Kramer, S. Metz, K.B. Peterson, B.S. Pitzele, F.S. Tjoeng, M.V. Toth, M. Trivedi, , R.K. Webber, S. Tsymbalov, R.E. Gapud
  1. US patent 6,207,708, 3/27/01
    “Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors” Hansen Jr., D.W.; Bergmanis, A.A.; T.J. Hagen, E.A. Hallinan, S.W. Kramer, S. Metz, K.B. Peterson, B.S. Pitzele, F.S. Tjoeng, M.V. Toth, M. Trivedi, , R.K. Webber, S. Tsymbalov, R.E. Gapud
  1. S. Patent 6,143,790, 11/7/00
    "L-N6-(1-iminoethyl)lysine Derivatives Useful as Nitric Oxide Synthase Inhibitors."
    Hallinan, E.A.; Tjoeng, F.S.; Fok, K.F.; Hagen, T.J.; Toth, M.V.; Tsymbalov, S.; Pitzele, B.S.
  1. S. Patent 6,136,829, 10/24/00
    "Oxathiadiazole derivatives as useful iNOS inhibitors”. Hansen Jr., D.W.; Bergmanis, A.A.; T.J. Hagen, E.A. Hallinan, S.W. Kramer, S. Metz, K.B. Peterson, B.S. Pitzele, F.S. Tjoeng, M.V. Toth, M. Trivedi, , R.K. Webber, S. Tsymbalov, R.E. Gapud
  1. S. Patent 6,071,906, 6/6/00
    "Imidino Piperidine Derivatives Useful as Nitric Oxide Synthase Inhibitors”. D.W. Hansen Jr., A.A. Bergmanis, T.J. Hagen, E.A. Hallinan, S.W. Kramer, S. Metz, K.B. Peterson, B.S. Pitzele, F.S. Tjoeng, M.V. Toth, M. Trivedi, , R.K. Webber, S. Tsymbalov, R.E. Gapud
  1. S. Patent 6,046,21, 4/4/00
    "Amidino Derivatives Useful as Nitric Oxide Synthase Inhibitors”. D.W. Hansen Jr., A.A. Bergmanis, T.J. Hagen, E.A. Hallinan, S.W. Kramer, S. Metz, K.B. Peterson, B.S. Pitzele, F.S. Tjoeng, M.V. Toth, M. Trivedi, , R.K. Webber, S. Tsymbalov, R.E. Gapud.
  1. S. Patent 6,136,829, 3/28/00
    "Pyrrolodino Imidines Useful as Nitric Oxide Synthase Inhibitors.” D.W. Hansen Jr., A.A. Bergmanis, T.J. Hagen, E.A. Hallinan, S.W. Kramer, S. Metz, K.B. Peterson, B.S. Pitzele, F.S. Tjoeng, M.V. Toth, M. Trivedi, , R.K. Webber, S. Tsymbalov, R.E. Gapud.
  1. S. Patent 6,011,028, 1/4/00
    "Cyclic Amidino Agents Useful as Nitric Oxide Synthase Inhibitors". D.W. Hansen Jr., E.A. Hallinan, T.J. Hagen, S.W. Kramer, K.B. Peterson, D.P. Spangler, M.V. Toth, K.F. Fok, A.A. Bergmanis, R.K. Webber, M. Trivedi, F.S. Tjoeng, B.S. Pitzele
  1. S. Patent 5,981,556, 11/9/99
    "1,3-Diazolino and 1,3-Diazolidino Heterocycles as Useful Nitric Oxide Synthase Inhibitors”. D.W. Hansen Jr., E.A. Hallinan, T.J. Hagen, S. Tsymbalov, S.W. Kramer, S.S. Metz, K.B. Peterson, M.V. Toth, A.A. Bergmanis, R.K. Webber, M. Trivedi, R.E. Gapud, F.S. Tjoeng, and B.S. Pitzele.
  1. US Patent 5,981,511, 11/9/99
    “Hydroxyamidino Derivatives Useful as Nitric Oxide Synthase Inhibitors.” R.K. Webber, D.W. Hansen Jr., E.A. Hallinan, R.G. Gapud, T.J. Hagen, F.S. Tjoeng, S.S. Metz, M.V. Toth, B.S. Pitzele, A.A. Bergmanis, S. Tsymbalov, and R.E. Manning.
  1. S. Patent 5,958,958, 9/28/99
    “1,2,4--Oxa Diazolino and 1,2,4-Oxa Diazolidino Heterocycles as Useful Nitric Oxide Synthase Inhibitors.” D.W. Hansen Jr., E.A. Hallinan, T.J. Hagen, S. Tsymbalov, S.W. Kramer, S.S. Metz, K.B. Peterson, M.V. Toth, A.A. Bergmanis, R.K. Webber, M. Trivedi, R.E. Gapud, F.S. Tjoeng, and B.S. Pitzele
  1. S. Patent 5,883,251, 3/16/99
    “Azepine Derivatives Useful as Nitric Oxide Synthase Inhibitors.” D.W. Hansen, Jr., E. A. Hallinan, T.J. Hagen, S.W. Kramer, S. Metz, K. B. Peterson, D.P. Spangler, M.V. Toth, K.F. Fok, A.A. Bergmanis, R.K. Webber, M. Trivedi, F.S. Tjoeng, B.S. Pitzele.
  1. S. Patent 5,854,234, 12/29/98
    “Amidino Derivatives Useful as Nitric Oxide Synthase Inhibitors.” D.W. Hansen, Jr., M.G. Currie, E. A. Hallinan, K.F. Fok, T.J. Hagen, A.A. Bergmanis, S.W. Kramer, L.F. Lee, S. Metz, K. B. Peterson, B.S. Pitzele, D.P. Spangler, R.K. Webber, M.V. Toth, M. Trivedi, F.S. Tjoeng.
  1. S. Patent 5,719,140, 2/17/98
    “2,3-,4-,5-,6-,7-,8-,9- and/or 10-Substituted Dibenzoxazepine Compounds, Pharmaceutical Compositions and Methods of Use.” N. S. Chandrakumar, T. J. Hagen, B. S. Pitzele, S. Tsymbalov, E. A. Hallinan.
  1. S. Patent No. 5,677,296, 10/14/97
    “Carbamic Acid Derivatives of Substituted Dibenzoxazepine Compounds, Pharmaceutical Compositions and Methods of Use” E. A. Hallinan, T. J. Hagen,
  1. S. Patent No. 5,488,046, 5/20/97
    “Process For The Preparation of 3S-[[4-[[4-(aminoiminoethyl)-phenyl]amino]-1,4-dioxobutyl] amino]-4-pentynoate.” D.W. Hansen Jr., E.A. Hallinan, T.J. Hagen, K.B. Peterson, B.S. Pitzele, K. McLaughlin, S. Tsymbalov, J. Behling, J.M. Park, S.S. Babu, D. Konte, V. Orlouski, M. Boys, W. Doubleday, K.J. Cain-Janicki, J.R. Medich, P. Farid, K. Babiak, S. Nugent, and D. Pilipauskas.
  1. S. Patent No. 5,576,315; 11/01/96
    “Substituted Dibenzoxazepine Compounds and Methods for Treating Osteoporosis and Ischemia.” E. A. Hallinan, T. J. Hagen, R. K. Husa, S. Tsymbalov, A. C. Lee, J-P Van Hoeck.
  1. S. Patent No. 5,488,046; 1/30/96
    “Carbamic Acid Derivatives of Substituted Dibenzoxazepine Compounds, Pharmaceutical Compositions and Methods of Use.”  E. A. Hallinan, T. J. Hagen
  1. S. Patent No. 5,464,830; 11/7/95
    “Substituted Dibenzoxazepine Compounds, Pharmaceutical Compositions and Methods of Use.” E. A. Hallinan, T. J. Hagen, R. K. Husa, S. Tsymbalov, A. C. Lee, J-P Van Hoeck.
  1. US Patent No. 5,461,046; 10/24/95
    “1-, 2-,3-,4-, 5- 6-, 7-, 8-, and/or 9-Substituted Dibenzoxazepine Compounds, Pharmaceutical Compositions and Methods for Treating Pain.” T.J. Hagen, E.A. Hallinan, M.F. Rafferty, R.K. Husa;
  1. US Patent 5,449,674; 9/12/95
    “2-,3-,5- and/or 8-Substituted Dibenzoxazepine Compounds, Pharmaceutical Compositions and Methods for Treating Pain.”  T.J. Hagen, E.A. Hallinan, N.S. Chandrakumar, S.N. Rao, B.S. Pitzele
  1. US Patent 5,449,673; 9/12/95
    “10,11-Dihydro -10-(3-substituted-1-oxo-2-propyl, propenyl or propynyl) Dibenz[B,F] [1,4]oxazepine Prostaglandin Antagonists.” N.S. Chandrakumar, T.J. Hagen, E.A. Hallinan, R.K. Husa.
  1. US Patent No. 5,395,932; 3/7/95
    “2,3,5,7,8 and/or 10-Substituted Dibenzoxazepine Compounds, Pharmaceutical Compositions and Methods of Use.” N.S. Chandrakumar, T.J. Hagen, B.S. Pitzele, S. Tsymbalov, E.A. Hallinan
  1. US Patent No. 5,382,578; 1/17/95
    “Methods for Treating Convulsions and Ischemia with Substituted Dibenzoxazepine Compounds.” R.K. Husa, T.J. Hagen, E.A. Hallinan
  1. S. Patent No. 5,378,840; 1/3/95
    “Substituted Dibenzoxazepine Compounds.” E.A. Hallinan, T.J. Hagen, S. Tsymbalov, R.K. Husa, J.P. Van Hoeck, A.C. Lee
  1. US Patent No. 5,324,722; 6/28/94
    “1-, 2-,3-,5-,8-,10- and/or 11-Substituted Dibenzoxazepine Compounds, Pharmaceutical Compositions and Methods for Treating Pain.” T.J. Hagen, M. Clare, M.F. Rafferty, E.A. Hallinan
  1. S. Patent No. 5,304,644; 4/19/94
    “2-,3-,4-,5-,6-,7-,8- and or 9 Substituted Dibenzoxazepine compounds, Pharemaceutical Composistions and Methods for Treating Pain.”  R.K. Husa, M.F. Rafferty, T.J. Hagen, E.A. Hallinan
  1. US Patent No. 5,288,719; 2/22/94
    “2-3-,8- and/or 10-Substituted Dibenzoxazepine Compounds, Pharmaceutical Compositions and Methods for Treating Osteoporosis.” R.K. Husa, T.J. Hagen, E.A. Hallinan
  1. US Patent No. 5,212,169; 5/18/93
    “Substituted Dibenzoxazepine Compounds, Pharmaceutical Compositions and Methods of Use.” R.K. Husa, T.J. Hagen, E.A. Hallinan

Contact Us

Faraday Hall 350
Northern Illinois University
DeKalb, IL 60115

Phone: 815-753-1463
Fax: 815-753-2902
Email: thagen@niu.edu

Mailing Address

Timothy J. Hagen, Ph.D.
Department of Chemistry and Biochemistry
Northern Illinois University
1425 W. Lincoln Hwy.
DeKalb, IL 60115‐2828
Back to top