Publications in the Meganathan Lab

Goshu, G., M. D. Ghose, J. M. Bain, P. G. Pierce, D. W. Begley, S. N. Hewitt, H. S. Udell, P. J. Myler, R. Meganathan, T. J. Hagen. (2015). Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents. Bioorganic & Medicinal Chemistry Letters, Volume 25, Issue 24, Pages 5699–5704. Supplement 19 pages.

Meganathan, R. and O. Kwon.2014. Biosynthesis of Menaquinone (Vitamin K2) and Ubiquinone (Coenzyme Q). NIH Public Access, Ecosal Plus, Pages 1-37. Author manuscript; available in PMC 2014 September 23.

Vos, M.,G. Esposito, J. N. Edirisinghe, S. Vilain, D. M. Haddad, J. R. Slabbaert, S. Van Meensel, O. Schaap, B. De Strooper, R. Meganathan, V. A. Morais, and P. Verstreken. 2012. Vitamin K2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency. Science: 336:1306-1310 (2012).

Ranganathan, Y., S. Patel*.,V. K. Pasupuleti and R. Meganathan. (2010).  Protein hydrolysates from non-bovine and plant sources replaces tryptone in microbiological media. Chapter 7, pp 115-125.  In V.K. Pasupuleti and A.L. Demain, (Eds.), Protein hydrolysates in biotechnology,  Springer.

Meganathan, R. (2010).  Menaquinone/Ubiquinone Biosynthesis and Enzymology. In Comprehensive Natural Products II: Chemistry and Biology, Editors-In-Chief  Lewis Mander and Hung-Wen Liu; Volume 7. Pp. 411-444.  “Cofactors” Edited by Tadhg Begley. Elsevier Science.

Meganathan, R. and O. Kwon. 2008. Biosynthesis of Menaquinone (Vitamin K2) and Ubiquinone (Coenzyme Q). January 2009, posting date. Chapter, In A. Böck, R. Curtiss III, J. B. Kaper, P. D. Karp, F. C. Neidhardt, T. Nyström, J. M. Slauch, C. L. Squires, and D. Ussery (ed.), EcoSal-Escherichia coli and Salmonella: cellular and molecular biology. American Society for Microbiology, Washington, DC.

Meganathan. R., Y. Ranganathan and C. A. Reddy.  2007.  Carbohydrate fermentations. pp 558-585. In C. A. Reddy, T. J. Beveridge, J. A. Breznak, G. A. Marzluff, and T. M. Schmidt (ed.), Methods for General and Molecular Microbiology, American Society for Microbiology, Washington, D.C.

Kwon, O., M. Druce-Hoffman, and R. Meganathan.  2005.  Regulation of the ubiquinone (Coenzyme Q) biosynthetic genes ubiCA in Escherichia coli. Curr. Microbiol.  50:180-189.

Lee, K., X. Zhan, J. Gao, J. Qiu, Y. Feng, R. Meganathan, S. N. Cohen, and G Georgiou. 2003. RraA: a protein inhibitor of RNase E activity that globally modulates RNA abundance in E. coli. Cell 114:623-634.

Meganathan, R. 2001. Biosynthesis of menaquinone (vitamin K2) and ubiquinone (coenzyme Q): A perspective on enzymatic mechanisms. Vitamins and Hormones, 61:173-218.

Meganathan, R. 2001.Ubiquinone biosynthesis in microorganisms. FEMS Microbial. (MiniReview). 203:131-139.

Thompson, T., J. B., Garrett, E. A. Taylor, R. Meganathan, J. S. Gerlt, and I Rayment. 2000. Evolution of enzymatic activity in the enolase superfamily: Structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate. Biochemistry 39:10662-10676.

Kwon, O., A. Kotsakis and R. Meganathan. 2000 Ubiquionone (Coenzyme Q) biosynthesis in Escherichia coli: localization, isolation, and identification of ubiF gene. FEMS Microbiol. Lett. 186: 157-161.

Palmer, D. R. J., Garret, J. B., Sharma, V., Meganathan, R., Babbitt, P. C., and Gerlt, J. A. 1999 Unexpected divergence of enzyme function and sequence: N-acylamino acid racemase is o-succinylbenzoate synthase. Biochemistry. 38:4252-4258.

Suvarna, K., D. Stevenson, R. Meganathan, and M.E.S. Hudspeth. 1998. Menaquinone (vitamin K2) biosynthesis: Localization and characterization of the menA gene from Escherichia coli. J. Bacteriol. 180:2782-2787.

Daruwala, R., D.K. Bhattacharyya, O. Kwon and R. Meganathan. 1997. Menaquinone (vitamin K2) biosynthesis: overexpression, purification and characterization of a new Isochorismate synthase from Escherichia coli. J. Bacteriol. 179:3133-3138.

Bhattacharyya, D.K., O. Kwon and R. Meganathan. 1997. Vitamin K2 (menaquinone) biosynthesis in Escherichia coli: Evidence for the presence of an essential histidine residue in o-succinylbenzoyl coenzyme A synthetase. J. Bacteriol. 179:6061-6065.

Kwon, O., D.K. Bhattacharyya and R. Meganathan. 1996. Menaquinone (vitamin K2) biosynthesis: Overexpression, purification and properties of o-succinylbenzoyl-coenzyme A synthetase from Escherichia coli. J. Bacteriol. 178:6778-6781.

Daruwala, R., O. Kwon, R. Meganathan and M. E. S. Hudspeth. 1996. A new isochorismate synthase specifically involved in menaquinone (vitamin K2) biosynthesis encoded by the menF gene. FEMS Microbiology Lett. 140:159-164.

Kwon, O., M.E.S. Hudspeth and R. Meganathan. 1996. Anaerobic biosynthesis of enterobactin in Escherichia coli.: Regulation of entC gene expression and evidence against its involvement in menaquinone (Vitamin K2) biosynthesis J. Bacteriol. 178:3252-3259.

Sharma, V., M.E.S. Hudspeth, and R. Meganathan. 1996. Menaquinone (vitamin K2) biosynthesis: Localization and characterization of the menE gene from Escherichia coli. Gene 168:43-48.

Meganathan, R. 1996. Biosynthesis of the isoprenoid quinones menaquinone (vitamin K2) and ubiquinone (coenzyme Q), p. 642-656. In F. C. Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella: Cellular and molecular biology. American Society for Microbiology, Washington, D.C.

Palaniappan, C., Taber, H., Meganathan, R. 1994. Biosynthesis of o-succinylbenzoic acid in Bacillus subtilis: Identification of menD mutants and evidence against the involvement of the 2-ketoglutarate dehydrogenase complex. J. Bacteriol. 176:2648-2653.

Sharma, V., Meganathan, R., Hudspeth, M.E.S. 1993. Menaquinone (vitamin K2) biosynthesis: Cloning, nucleotide sequence and expression of menC gene from Escherichia coli. J. Bacteriol. 175:4917-4921.

Heinkel, C.M., Hudspeth, M.E.S., Meganathan, R., Zinnen, T.M. 1992. Further characterization of mycolamanaran-induced resistance: Temperature sensitivity against tobacco mosaic virus, and function against califlower mosaic virus and tomato spotted wilt virus. Phytopathology 82:637-641.

Sharma, V., Suvarna, K., Meganathan, R., Hudspeth, M.E.S. 1992. Menaquinone (Vitamin K2) biosynthesis: Nucleotide sequence and expression of the menB gene from Eschrichia coli. J. Bacteriol. 174:5057-5062.

Palaniappan, C., Sharma, V., Hudspeth, M.E.S., Meganathan, R. 1992. Menaquinone (Vitamin K2) biosynthesis: Evidence that the Escherichia coli menD gene encodes both 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase and 2-ketoglutarate decarboxylase activities. J. Bacteriol. 174:8111-8118.

Miguel, L., Meganathan, R. 1991. Electron donors and the quinone involved in dimethyl sulfoxide reduction in Escherichia coli. Curr. Microbiol 22:109-115.

Zinnen, T.M., Heinkel, C.M., Hudspeth, M.E.S., Meganathan, R. 1991. Cytoplasmic mycolamanaran inhibits initial viral infection of certain Nicotiana species. Phytopathology 81:426-428.

Daruwala, R., Meganathan, R. 1991. Dimethyl sulfoxide reductase is not required for trimethylamine N-oxide reduction in Escherichia coli. FEMS Microbiol. Lett. 83:255-260.

Valentine-Serano, A., Hudspeth, M.E.S., R. Meganathan, R. 1991. Reduction of N- oxides and sulfoxide by the same terminal reductase in Proteus mirabilis. Curr. Microbiol. 23:271-276.

Coffell, R., Hudspeth, M.E.S., Meganathan, R. 1990. Biochemical evidence for the exclusion of Zoophagus insidians from the Oomycetes. Mycologia 82:326-331.

Bentley, R. and R. Meganathan. 1987. The biosynthesis of isoprenoid quinones ubiquinone and menaquinone.  In F.C. Neidhardt, J. Ingraham, K.B.  Low, B.  Magasanik, M. Schaechter, and H.W. Umbargar (eds.)  Escherichia coli and Salmonella typhinurium cellular and molecular biology. p. 512-520.  American Society for Microbiology, Washington, D.C.

Meganathan, R. and L. Miguel. 1987. Dimethyl sulphoxide respiration in Proteus mirabilis. Microbios 51:191-201.

Meganathan, R. and J. Schrementi. 1987. Tetrahydrothiophene 1-oxide as an electron acceptor for Escherichia coli. J. Bacteriol. 169:2862-2865.

Schrementi, J. and R. Meganathan. 1987. A gas chromatographic method for the determination of tetrahydrothiophene produced by enzymatic reduction of tetrahydrothiophene-1-oxide. Microbios Lett. 35:79-85.

Marley, M.G., R. Meganathan and R. Bentley. 1986. Menaquinone (vitamin K2) biosynthesis in Escherichia coli:  Synthesis of o-succinylbenzoate does not require the decarboxylase activity of the Ketoglutanate dehydrogenase complex. Biochemistry 25:1304-1307.

Meganathan, R. and R. Coffell. 1985. Identity of the quinone in Bacillus alcalophilus. J. Bacteriol. 164:911-913.

Meganathan, R. 1984. Inability of men mutants of Escherichia coli to use trimethylamine-N-oxide as an electron acceptor. FEMS Microbiol. Lett. 24:57-62.

Shaw, D.J, E.C. Robinson, R. Meganathan, R. Bentley and J.R. Guest. 1983.  Recombinant plasmids containing menaquinone biosynthetic genes of Escherichia coli.  FEMS Microbiol. Lett. 17:63-67.

Meganathan, R., and R. Bentley. 1983. Thiamine pyrophosphate requirement for o-succinylbenzoic acid synthesis in Escherichia coli and evidence for an intermediate. J. Bacteriol. 153:739-746.

Bentley, R., and R. Meganathan. 1983. Vitamin-K biosynthesis in bacteria-precursors, intermediates, enzymes and genes. J. Natural Prod. 46:44-59.

Bentley, R., and R. Meganathan. 1982. Biosynthesis of vitamin K (Menaquinone) in bacteria. Microbiol. Reviews 46:241-280.

Shaw, D.J., J.R. Guest, R. Meganathan and R. Bentley. 1982. Characterization of Escherichia coli men mutants defective in conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoate. J. Bacteriol. 152:1132-1137.

Castric, P.A., K.F. Castric and R. Meganathan. 1981. Factors influencing the termination of cyanogenesis in Pseudomonas aeruginosa. p. 263-274. In B.  Vennesland, E.E. Conn, C.J. Knowles, J. Westley, and F. Wissing (eds.) Cyanide in Biology. Academic Press, London.

Meganathan, R., R. Bentley and H. Taber. 1981. Identification of Bacillus subtilis men mutants which lack o-succinylbenzoyl-Coenzyme A synthetase and dihydroxynaphthoate synthase. J. Bacteriol. 145:328-332.

Bentley, R. and R. Meganathan. 1981. Biosynthesis of geosmin and methylisoborneol in Streptomycetes. Evidence for an isoprenoid pathway and its absence in non-differentiating isolates. FEBS Letters 125:220-222.

Meganathan, R. and R. Bentley. 1981. Biosynthesis of o-succinylbenzoic acid in a men- Escherichia coli mutant requires decarboxylation of L-glutamate at the C‑1 position. Biochemistry 20:5336-5340.

Meganathan, R. 1981. Enzymes from Escherichia coli synthesize o-succinylbenzoic acid, an intermediate in menaquinone (Vitamin K2) biosynthesis.  J. Biol.  Chem. 256:9386-9388.

Meganathan, R., T. Folger and R. Bentley. 1980. Conversion of o-succinylbenzoate to dihydroxynaphthoate by extracts of Micrococcus luteus.  Biochemistry 19:785-789.

Meganathan, R. 1979. Why has the "nitrogenase plasmid" snubbed the Pseudomonads? J. Theoretical Biol. 80:301-304.

Meganathan, R., T. Folger and R. Bentley. 1979. Enzymes involved in vitamin K biosynthesis. p. 188-192. In J.W. Suttie (ed) Vitamin K Metabolism and Vitamin K-dependent Proteins. University Park Press, Baltimore.

Meganathan, R. and R. Bentley. 1979. Menaquinone (vitamin K2) biosynthesis:  Conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes. J. Bacteriol. 140:92-98.

Meganathan, R. and P.A. Castric. 1977. The effect of inorganic phosphate on cyanogenesis by Pseudomonas aeruginosa. Arch. Microbiol. 114:51-54.

Prihar, H.S., R. Meganathan, and D.S. Feingold. 1978. Loss of C-5 hydrogen during conversion of D-glucuronic acid to methyl-a-D-glucopyronoside.  Carbohydr. Res. 67:271-274.

Meganathan, R. and J.C. Ensign. 1976. Stability of enzymes in starving Arthrobacter crystallopoietes. J. Gen. Microbiol. 94:90-96.

Holtzer, H., J. Biehl, G. Yeoh, R. Meganathan and A. Kaji. 1975. Effect of oncogenic virus on muscle differentiation. Proc. Nat. Acad. Sci. USA, 72:4051-4055.

Meganathan, R. and R.E. Marquis. 1973. Loss of bacterial motility under pressure. Nature (London) 246:525-527.


Photo of R. Meganathan
Rangswamy Meganathan
(815) 753-7803
Office: MO 318
Lab: MO. 319
Dept. of Biological Sciences
Nothern Illinois University
DeKalb, IL 60115