Are you going to be away from your GroupWise mailbox for a day or more? An out of office rule automatically replies to your e-mails while you're away.
It's a good idea to state your return date, an alternate way to contact you if appropriate, and another person who is covering for you if appropriate.
In GroupWise, Tools > Vacation Rule
Check the "Activate my vacation rule" box.
Write the message people will get from you.
If you are on a listserv, you may not want to reply to external users.
Choose the dates the rule will be in effect.