Timothy Hagen joins the NIU chemistry faculty

Timothy J. Hagen joined the NIU faculty as an assistant professor of organic chemistry in August 2010. He received his bachelor's degree from Illinois State University and his Ph.D. degree from the University of Wisconsin - Milwaukee. He did postdoctoral research for Searle.

Prior to NIU, Tim worked in the pharmaceutical industry as a synthetic organic and medicinal chemist for more than 20 years. He worked for Searle, Pharmacia and Pfizer (all the same company through multiple mergers), and deCODE. He is an author on 35 journal articles, an inventor on 42 patents and patent applications, and a contributing author to three books. One of the compounds he worked on at Pfizer, SD-6010, is currently in Phase II clinical trials for the treatment of osteoarthritis.

Hagen's prior teaching experience includes being an adjunct faculty at Northwestern University in Evanston, teaching graduate level courses in synthetic organic and physical organic chemistry, and a visiting professor at NIU, teaching organic synthesis and introductory chemistry.

Tim's research group will focus on organic synthesis and medicinal chemistry. The focus is on synthesis of small molecules that can modulate essential pathways of infectious disease organisms. The disease targets include parasitic diseases and bacterial infections. The Hagen lab utilizes protein fragment-based screening, de novo drug design and natural product chemistry to explore enzyme inhibition and selectivity. Specific areas of interest include: (1) fragment-based design of novel small-molecules to selectively disrupt key enzymatic interactions in the non-mevalonate isoprenoid biosynthetic pathway; (2) design of novel small-molecules to selectively inhibit the malarial and bacterial forms of enzymes such as MetAP2; and (3) synthetic methodology to natural products, such as the bengamides. The bengamides show anticancer, antibiotic and anti-malarial properties. The Hagen group uses a multidisciplinary approach toward achieving these research goals including synthetic organic chemistry, computer modeling, protein crystallography, molecular and cell biology.

Tim currently lives in Lisle with his wife, Cindy, and three children, Amanda, Erica and Jacob.